An article on the frailty syndrome, authored by M. Jane Mohler, Mindy J. Fain, Anne M. Wertheimer, Bijan Najafi, and Janko Nikolich-Žugich, has been published in Experimental Gerontology, Volume 54, June 2014, Pages 6–13.
- There is a lack of fundamental understanding and of animal models to study frailty.
- We discuss key theories of frailty—cytokine dysfunction and mitochondrial disorder.
- There is a need for objective human measures using biosensors and imaging.
- We review recent breakthroughs correlating animal and human frailty measures.