Kristian Doyle, Ph.D.

Assistant Professor, Departments of Immunobiology and Neurology

Research Interest: Immunobiology and Neurology

 

Education:
Ph.D:  Oregon Health & Science University, Portland, OR,  Mol. Microbiology & Immunology 2001-2007
BS:  University of Sussex, Brighton, UK  Biology; minor in North American Literature 1996-2000
 
Honors and Awards:
  • 2010: Recipient of the Anita Roberts Young Scientist Scholarship
  • 2010: Invited speaker: Keystone Conference on TGF-beta in Immune Responses: From Bench to Bedside, Snowbird, Utah.
  • 2010: Invited Reviewer for Neuropharmacology
  • 2009: American Federation of Aging Research Postdoctoral Fellowship
  • 2009: Ellison Medical Foundation Fellowship to attend Molecular Biology of Aging Summer course, Marine Biological Laboratory, Woods Hole, MA, USA
  • 2005: Hot Topic Travel Award to attend Gordon Conference on Small Integrin Binding Proteins, Big Sky, Montana
  • 2005: Invited speaker: Gordon Conference on Small Integrin Binding Proteins, Big Sky, Montana
  • 2003: N.L Tartar Research Fellowship

Societies:

  • 2001-present   Member, Society for Neuroscience

Publications:

  1. K.P. Doyle, R.P. Simon, A. Snyder, M.P. Stenzel-Poore. Working with GFP in the Brain. Biotechniques, 34:492-494, 2003.
  2. R.Meller, S. Stevens, M. Minami, J. Cameron, S. King, H. Rosenzweig, K.P. Doyle, N. Lessov, R. Simon and M. Stenzel-Poore. Neuroprotection by Osteopontin in Stroke. Journal of Cerebral Blood Flow and Metabolism. 25 (2):217-225, 2005.
  3. K.P. Doyle, K.L. Suchland, T.M.P. Ciesielski, N.S. Lessov, D.K. Grandy, T. S. Scanlan, and M. P. Stenzel-Poore. Novel Thyroxine Derivatives, Thyronamine and 3-iodothyronamine, Induce Transient Hypothermia and Marked Neuroprotection Against Stroke Injury. Stroke, 38:2569-2576, 2007.
  4. K.P. Doyle, M.P. Stenzel-Poore, and R.P. Simon. Mechanisms of ischemic brain damage. Neuropharmacology, 55 (3):310-8, 2008.
  5. K.P. Doyle, S.L. Stevens, N.S. Lessov, T. Yang, T.M.P. Ciesielski, R.P. Simon, J.S. King, and M.P. Stenzel-Poore. Nasal administration of osteopontin peptide mimetics confers robust neuroprotection in stroke. Journal of Cerebral Blood Flow and Metabolism, 28 (6):1235-48, 2008
  6. G.A. West, K.J. Golshani, K.P. Doyle, N.S. Lessov, T.R. Hobbs, S.G.  Kohama, M.M. Pike, C.D. Kroenke, M.R. Grafe, M.D. Spector, E.T. Tobar, R.P. Simon and M.P. Stenzel-Poore. A new model of cortical stroke in the rhesus macaque: Journal of Cerebral Blood Flow and Metabolism, 29 (6):1175-86, 2009.
  7. K.P. Doyle, E. Cekanaviciute, L.E. Mamer, M.S. Buckwalter. TGF-beta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke: Journal of Neuroinflammation. 2010 Oct 11;7(1):62
  8. F.R. Bahjat, R.L. Williams-Karnesky, S.G. Kohama, G.A. West, K.P. Doyle, N.S. Lessov, M.D. Spector, T.R. Hobbs, and M.P. Stenzel-Poore. Proof of Concept: Pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke: Journal of Cerebral Blood Flow and Metabolism, 31 (5): 1229-42, 2011
  9. A. Csiszar, A. Podlutsky, N. Podlutskaya, W.E. Sonntag, S.Z. Merlin, E.E. Philipp, K. Doyle, A. Davila, F.A. Recchia, P. Ballabh, J.T. Pinto and Z. Ungvari.Testing the Oxidative Stress Hypothesis of Aging in Primate Fibroblasts: Is There a Correlation Between Species Longevity and Cellular ROS Production? The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 67 (8): 841-52, 2012  
  10. K.P Doyle, N. Fathali, M.R. Siddiqui, and M.S. Buckwalter. Distal hypoxic stroke: A new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit. Journal of Neuroscience Methods, 207 (1): 31-40, 2012
  11. J. Han, J. Pollak, T. Yang, M.R. Siddiqui, K.P. Doyle, K. Taravosh-Lahn, E. Cekanaviciute, A. Han, J.Z. Goodman, B. Jones, D. Jing, S.M. Massa, F.M. Longo, and M.S. Buckwalter. Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic–Ischemic Stroke. Stroke. 43(7) 1918-24, 2012
  12. K.P. Doyle and M.S. Buckwalter, The double-edged sword of inflammation after stroke: What sharpens each edge? Annals of Neurology. 71(6):729-31, 2012
  13. J. Pollak, K.P. Doyle, L. Mamer, M. Shamloo, and M.S. Buckwalter. Stratification substantially reduces variability in the hypoxic-ischemic stroke model. Brain and Behaviour. 2 (5):698-706, 2012
  14. E. Cekanaviciute, N. Fathali, K.P. Doyle, A.M. Williams, J. Han, and M.S. Buckwalter. Astrocytic transforming growth factor-Beta signaling reduces subacute neuroinflammation after stroke in mice. Glia, 2014 In Press.

 

Books, Chapters, Special Issues

  • K.P. Doyle and M.S. Buckwalter, A Mouse Model of Permanent Focal Ischemia: Distal Middle Cerebral Artery Occlusion. Richard Milner (ed.), Cerebral Angiogenesis: Methods and Protocols, Methods in Molecular Biology, vol. 1135, 2014

Ongoing Research Support

K99/R00 – PI: Kristian Doyle    04/01/12 - 04/01/17

National Institute of Nursing Research, NIH

Title: Inflammation and delayed cognitive dysfunction after stroke

The goal of this project is to investigate if chronic inflammation after stroke is one cause of post stroke dementia, a sub-category of vascular dementia, the second most common form of dementia in the US.

Completed Research Support

Postdoctoral Fellowship – PI: Kristian Doyle    07/01/09 – 06/30/10

American Federation for Aging Research     

Title: Does increased TGF-b signaling in the elderly increase astrogliosis and impair functional recovery following stroke?

The goal of this project was to understand how aging affects astrogliosis and TGF-b signaling after stroke to help develop treatments that are tailored to elderly patients.