Research Interest: Immunobiology and Neurology
Ph.D: Oregon Health & Science University, Portland, OR, Mol. Microbiology & Immunology 2001-2007
BS: University of Sussex, Brighton, UK Biology; minor in North American Literature 1996-2000
Honors and Awards:
- 2010: Recipient of the Anita Roberts Young Scientist Scholarship
- 2010: Invited speaker: Keystone Conference on TGF-beta in Immune Responses: From Bench to Bedside, Snowbird, Utah.
- 2010: Invited Reviewer for Neuropharmacology
- 2009: American Federation of Aging Research Postdoctoral Fellowship
- 2009: Ellison Medical Foundation Fellowship to attend Molecular Biology of Aging Summer course, Marine Biological Laboratory, Woods Hole, MA, USA
- 2005: Hot Topic Travel Award to attend Gordon Conference on Small Integrin Binding Proteins, Big Sky, Montana
- 2005: Invited speaker: Gordon Conference on Small Integrin Binding Proteins, Big Sky, Montana
- 2003: N.L Tartar Research Fellowship
- 2001-present Member, Society for Neuroscience
- K.P. Doyle, R.P. Simon, A. Snyder, M.P. Stenzel-Poore. Working with GFP in the Brain. Biotechniques, 34:492-494, 2003.
- R.Meller, S. Stevens, M. Minami, J. Cameron, S. King, H. Rosenzweig, K.P. Doyle, N. Lessov, R. Simon and M. Stenzel-Poore. Neuroprotection by Osteopontin in Stroke. Journal of Cerebral Blood Flow and Metabolism. 25 (2):217-225, 2005.
- K.P. Doyle, K.L. Suchland, T.M.P. Ciesielski, N.S. Lessov, D.K. Grandy, T. S. Scanlan, and M. P. Stenzel-Poore. Novel Thyroxine Derivatives, Thyronamine and 3-iodothyronamine, Induce Transient Hypothermia and Marked Neuroprotection Against Stroke Injury. Stroke, 38:2569-2576, 2007.
- K.P. Doyle, M.P. Stenzel-Poore, and R.P. Simon. Mechanisms of ischemic brain damage. Neuropharmacology, 55 (3):310-8, 2008.
- K.P. Doyle, S.L. Stevens, N.S. Lessov, T. Yang, T.M.P. Ciesielski, R.P. Simon, J.S. King, and M.P. Stenzel-Poore. Nasal administration of osteopontin peptide mimetics confers robust neuroprotection in stroke. Journal of Cerebral Blood Flow and Metabolism, 28 (6):1235-48, 2008
- G.A. West, K.J. Golshani, K.P. Doyle, N.S. Lessov, T.R. Hobbs, S.G. Kohama, M.M. Pike, C.D. Kroenke, M.R. Grafe, M.D. Spector, E.T. Tobar, R.P. Simon and M.P. Stenzel-Poore. A new model of cortical stroke in the rhesus macaque: Journal of Cerebral Blood Flow and Metabolism, 29 (6):1175-86, 2009.
- K.P. Doyle, E. Cekanaviciute, L.E. Mamer, M.S. Buckwalter. TGF-beta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke: Journal of Neuroinflammation. 2010 Oct 11;7(1):62
- F.R. Bahjat, R.L. Williams-Karnesky, S.G. Kohama, G.A. West, K.P. Doyle, N.S. Lessov, M.D. Spector, T.R. Hobbs, and M.P. Stenzel-Poore. Proof of Concept: Pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke: Journal of Cerebral Blood Flow and Metabolism, 31 (5): 1229-42, 2011
- A. Csiszar, A. Podlutsky, N. Podlutskaya, W.E. Sonntag, S.Z. Merlin, E.E. Philipp, K. Doyle, A. Davila, F.A. Recchia, P. Ballabh, J.T. Pinto and Z. Ungvari.Testing the Oxidative Stress Hypothesis of Aging in Primate Fibroblasts: Is There a Correlation Between Species Longevity and Cellular ROS Production? The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 67 (8): 841-52, 2012
- K.P Doyle, N. Fathali, M.R. Siddiqui, and M.S. Buckwalter. Distal hypoxic stroke: A new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit. Journal of Neuroscience Methods, 207 (1): 31-40, 2012
- J. Han, J. Pollak, T. Yang, M.R. Siddiqui, K.P. Doyle, K. Taravosh-Lahn, E. Cekanaviciute, A. Han, J.Z. Goodman, B. Jones, D. Jing, S.M. Massa, F.M. Longo, and M.S. Buckwalter. Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic–Ischemic Stroke. Stroke. 43(7) 1918-24, 2012
- K.P. Doyle and M.S. Buckwalter, The double-edged sword of inflammation after stroke: What sharpens each edge? Annals of Neurology. 71(6):729-31, 2012
- J. Pollak, K.P. Doyle, L. Mamer, M. Shamloo, and M.S. Buckwalter. Stratification substantially reduces variability in the hypoxic-ischemic stroke model. Brain and Behaviour. 2 (5):698-706, 2012
- E. Cekanaviciute, N. Fathali, K.P. Doyle, A.M. Williams, J. Han, and M.S. Buckwalter. Astrocytic transforming growth factor-Beta signaling reduces subacute neuroinflammation after stroke in mice. Glia, 2014 In Press.
Books, Chapters, Special Issues
- K.P. Doyle and M.S. Buckwalter, A Mouse Model of Permanent Focal Ischemia: Distal Middle Cerebral Artery Occlusion. Richard Milner (ed.), Cerebral Angiogenesis: Methods and Protocols, Methods in Molecular Biology, vol. 1135, 2014
Ongoing Research Support
K99/R00 – PI: Kristian Doyle 04/01/12 - 04/01/17
National Institute of Nursing Research, NIH
Title: Inflammation and delayed cognitive dysfunction after stroke
The goal of this project is to investigate if chronic inflammation after stroke is one cause of post stroke dementia, a sub-category of vascular dementia, the second most common form of dementia in the US.
Completed Research Support
Postdoctoral Fellowship – PI: Kristian Doyle 07/01/09 – 06/30/10
American Federation for Aging Research
Title: Does increased TGF-b signaling in the elderly increase astrogliosis and impair functional recovery following stroke?
The goal of this project was to understand how aging affects astrogliosis and TGF-b signaling after stroke to help develop treatments that are tailored to elderly patients.