Michael Kuhns, PhD
Michael Kuhns did his PhD training with James Allison at UC Berkeley studying the role that CTLA-4 plays in regulating CD4 T cell responses. He then went on to Stanford University for his postdoctoral studies with Mark Davis, studying the architecture and function of the TCR-CD3 complex, and joined the Department of Immunobiology at the University of Arizona in 2010. When in search of a mental diversion, he enjoys mountain biking and hiking in the local desert and sky islands.
Degrees
- BS: University of Arizona
- PhD: University of California, Berkeley
Fellowship
- Post-doctoral Fellow: Stanford University
Recent Publications
2018
Glassman, C. R., H. L. Parrish, M. S. Lee, and M. S. Kuhns, "Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex.", Cell Rep, vol. 22, issue 5, pp. 1263-1275, 2018 Jan 30. PMCID: PMC5813697 PMID: 29386113
Deshpande, N. R., J. L. Uhrlaub, S. Sing Way, J. Nikolich-Zugich, and M. S. Kuhns, "A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.", PLoS One, vol. 13, issue 6, pp. e0198354, 2018. PMCID: PMC5986155 PMID: 29864157
Lichauco, K., M. S. Lee, and M. S. Kuhns, "Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed.", Immunity, vol. 49, issue 5, pp. 786-788, 2018 11 20. PMID: 30462991
2016
Parrish, H. L., N. R. Deshpande, J. Vasic, and M. S. Kuhns, "Functional evidence for TCR-intrinsic specificity for MHCII.", Proc Natl Acad Sci U S A, 2016 Feb 1. PMID: 26831112
Glassman, C. R., H. L. Parrish, N. R. Deshpande, and M. S. Kuhns, "The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex.", J Immunol, vol. 196, issue 11, pp. 4713-22, 2016 06 01. PMCID: PMC4875830 PMID: 27183595
Bethune, M. T., M. H. Gee, M. Bunse, M. S. Lee, E. H. Gschweng, M. S. Pagadala, J. Zhou, D. Cheng, J. R. Heath, D. B. Kohn, et al., "Domain-swapped T cell receptors improve the safety of TCR gene therapy.", Elife, vol. 5, 2016 11 08. PMCID: PMC5101000 PMID: 27823582
Parrish, H. L., C. R. Glassman, M. M. Keenen, N. R. Deshpande, M. P. Bronnimann, and M. S. Kuhns, "Correction: A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.", PLoS One, vol. 11, issue 3, pp. e0150876, 2016. PMCID: PMC4773146 PMID: 26930656
2015
Parrish, H. L., C. R. Glassman, M. M. Keenen, N. R. Deshpande, M. P. Bronnimann, and M. S. Kuhns, "A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.", PLoS One, vol. 10, issue 7, pp. e0132333, 2015. PMCID: PMC4493003 PMID: 26147390
Lee, M. S., C. R. Glassman, N. R. Deshpande, H. B. Badgandi, H. L. Parrish, C. Uttamapinant, P. S. Stawski, A. Y. Ting, and M. S. Kuhns, "A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.", Immunity, vol. 43, issue 2, pp. 227-39, 2015 Aug 18. PMCID: PMC4545397 PMID: 26231119
Deshpande, N. R., H. L. Parrish, and M. S. Kuhns, "Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice.", Elife, vol. 4, pp. e05949, 2015. PMCID: PMC4501121 PMID: 26173205